BIMSA >
Seminar on Bioinformatics
An alignment-free method to find and visualize rearrangements between pairs of DNA sequences
An alignment-free method to find and visualize rearrangements between pairs of DNA sequences
Organizer
Speaker
Mengcen Guan
Time
Thursday, November 30, 2023 9:00 PM - 9:30 PM
Venue
Online
Abstract
Species evolution is indirectly registered in their genomic structure. The emergence and advances in sequencing technology provided a way to access genome information, namely to identify and study evolutionary macro-events, as well as chromosome alterations for clinical purposes. This paper describes a completely alignment-free computational method, based on a blind unsupervised approach, to detect large-scale and small-scale genomic rearrangements between pairs of DNA sequences. To illustrate the power and usefulness of the method we give complete chromosomal information maps for the pairs human-chimpanzee and human-orangutan. The tool by means of which these results were obtained has been made publicly available and is described in detail.