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生物信息讨论班
An alignment-free method to find and visualize rearrangements between pairs of DNA sequences
An alignment-free method to find and visualize rearrangements between pairs of DNA sequences
组织者
演讲者
关梦岑
时间
2023年11月30日 21:00 至 21:30
地点
Online
摘要
Species evolution is indirectly registered in their genomic structure. The emergence and advances in sequencing technology provided a way to access genome information, namely to identify and study evolutionary macro-events, as well as chromosome alterations for clinical purposes. This paper describes a completely alignment-free computational method, based on a blind unsupervised approach, to detect large-scale and small-scale genomic rearrangements between pairs of DNA sequences. To illustrate the power and usefulness of the method we give complete chromosomal information maps for the pairs human-chimpanzee and human-orangutan. The tool by means of which these results were obtained has been made publicly available and is described in detail.