The fundamental evolutionary theory of polygenic trait
With The mathematical theory of the evolution of complex traits as the clue, the final concern is the synthesis of palaeobiology theory and genetics theory, and the core contents of population genetics and quantitative genetics are connected around the evolutionary theory. Emphasis is placed on the introduction and lecture of mathematical content in population and quantitative genetics. This course is the lead course of "The evolutionary theory of polygenic trait - I".
本课程是一门讲授多基因性状的自然选择与长期演化理论的课程的初阶部分。课程总体以复杂性状的演化的数学理论为线索，以进化论中古生物学理论和遗传学理论的大综合为最终关切（这是未来进化生物学的某种方向和趋势）。在本部分中，围绕进化理论串联种群遗传学和数量遗传学核心内容，尤其注重对种群和数量遗传学中数学内容的介绍和串讲。本课程是"The evolutionary theory of polygenic trait - I"的先导课程。
本课程是一门讲授多基因性状的自然选择与长期演化理论的课程的初阶部分。课程总体以复杂性状的演化的数学理论为线索，以进化论中古生物学理论和遗传学理论的大综合为最终关切（这是未来进化生物学的某种方向和趋势）。在本部分中，围绕进化理论串联种群遗传学和数量遗传学核心内容，尤其注重对种群和数量遗传学中数学内容的介绍和串讲。本课程是"The evolutionary theory of polygenic trait - I"的先导课程。
Lecturer
Date
7th September ~ 28th December, 2026
Location
| Weekday | Time | Venue | Online | ID | Password |
|---|---|---|---|---|---|
| Monday | 14:20 - 16:55 | A3-2a-201 | Tencent 62 | 839 079 0573 | 271828 |
Syllabus
I overview of modern life sciences
II major goals of quantitative genetics and properties of distribution
III covariance, regression, and correlation of quantitative trait
IV Properties of single locus
V Sources of genetic variation for multilocus traits + Components of environmental variation
VI Resemblance between relatives
VII Polygenes and polygenic mutation
VIII neutral evolution in one and two-locus systems (1)
IX neutral evolution in one and two-locus systems (2)
X the genetic effective population size
XI the nonadaptive forces of evolution (1): drift, mutation and mutation rate
XII the nonadaptive forces of evolution (2) recombination and migration
XIII population genetics of selection (1)
XIV population genetics of selection (2)
XV interaction of selection, mutation and drift (1)
XVI interaction of selection, mutation and drift (2)
II major goals of quantitative genetics and properties of distribution
III covariance, regression, and correlation of quantitative trait
IV Properties of single locus
V Sources of genetic variation for multilocus traits + Components of environmental variation
VI Resemblance between relatives
VII Polygenes and polygenic mutation
VIII neutral evolution in one and two-locus systems (1)
IX neutral evolution in one and two-locus systems (2)
X the genetic effective population size
XI the nonadaptive forces of evolution (1): drift, mutation and mutation rate
XII the nonadaptive forces of evolution (2) recombination and migration
XIII population genetics of selection (1)
XIV population genetics of selection (2)
XV interaction of selection, mutation and drift (1)
XVI interaction of selection, mutation and drift (2)
Reference
Bruce Walsh & Michael Lynch. Evolution and Selection of Quantitative Traits. Oxford University Press. 2018.
Michael Lynch & Bruce Walsh. Genetics and Analysis of QUantitative Traits. Oxford University Press. 1998.
Daniel Hartl，Andrew Clark. Principles of Population Genetics, Fourth Edition, Sinauer Associates, Inc. 2007.
Warren J. Ewens. Mathematical Population Genetics. Springer. 2004-1.
刘祖洞、吴燕华、乔守怡、赵寿元。遗传学（第4版），高等教育出版社，2021-3.
Michael Lynch & Bruce Walsh. Genetics and Analysis of QUantitative Traits. Oxford University Press. 1998.
Daniel Hartl，Andrew Clark. Principles of Population Genetics, Fourth Edition, Sinauer Associates, Inc. 2007.
Warren J. Ewens. Mathematical Population Genetics. Springer. 2004-1.
刘祖洞、吴燕华、乔守怡、赵寿元。遗传学（第4版），高等教育出版社，2021-3.
Audience
Advanced Undergraduate
, Graduate
, Postdoc
Video Public
Yes
Notes Public
Yes
Language
Chinese
, English
Lecturer Intro
吴琦，2024年6月受聘于北京雁栖湖应用数学研究院，开展复杂性状演化建模。以（并列）一作或通讯作者在Science，Nature Genetics，PNAS，SCLS等期刊发表论文30余篇。