idopNetwork as a tool to dissect complex systems
Organizers
Speaker
Time
Wednesday, November 8, 2023 2:00 PM - 3:45 PM
Venue
Shuangqing-B725
Abstract
The past few years have seen the development of powerful computational models for reconstructing informative, dynamic, omnidirectional, and personalized networks (idopNetworks) of complex systems. We pack an R-based cartographic tool for idopNetwork reconstruction from any data. The tool includes several key steps, including fitting power curve fitting based on allometrical scaling law, functional clustering, LASSO-based variable selection, quasi-dynamic ordinary differential equation solving, species abundance decomposition and network visualization. Ultimately, it can coalesce all nodes into multilayer idopNetworks. We demonstrate the utility of this tool by analyzing different organs that are spatially interconnected via microbiomes using two datasets from the gut microbiota and plant microbiota. Given that biodiversity and organization vary biogeographically at different scales, idopNetwork will find its widespread application to modelling and estimating interspecific interactions with differing functions across space.
Speaker Intro
Dr.Dong received his education in Biotechnology and Silviculture at Zhejiang A&F University in 2018, then earned his Ph.D. at Beijing Forestry University in 2023. He is broadly interested in the role that network theory plays in paradigm shift in the life sciences, his current research lies at the area of statistical modelling and computer programming. He is working on how to fully utilize existing data to build a network which can analysis the detailed regulatory relationship between genes during the complicated biological process and how to make this idea come true. He also uses computer simulation that allows exploration and verification of design model parameters in multiple scenarios, and helps to further improve and understand the model as well as the complex systems.