BIMSA > Seminar on Bioinformatics Earliest modern human genomes constrain timing of Neanderthal admixture
Earliest modern human genomes constrain timing of Neanderthal admixture
Organizer
Shing Toung Yau
Speaker
Mengcen Guan
Time
Monday, December 23, 2024 10:00 AM - 10:30 AM
Venue
Online
Abstract
Modern humans arrived in Europe more than 45,000 years ago, overlapping at least 5,000 years with Neanderthals1–4. Limited genomic data from these early modern humans have shown that at least two genetically distinct groups inhabited Europe, represented by Zlatý kůň, Czechia3 and Bacho Kiro, Bulgaria2. Here we deepen our understanding of early modern humans by analyzing one high-coverage genome and five low-coverage genomes from ~45,000 year-old remains from Ilsenhöhle in Ranis, Germany4, and a further high-coverage genome from Zlatý kůň. We show that distant familial relationships link the Ranis and Zlatý kůň individuals and that they were part of the same small, isolated population that represents the deepest known split from the Out-of-Africa lineage. Ranis genomes harbor Neanderthal segments that originate from a single admixture event shared with all non-Africans that we date to ~45,000-49,000 years ago. This implies that ancestors of all non-Africans sequenced to-date resided in a common population at this time, and further suggests that modern human remains older than 50,000 years from outside Africa represent different non-African populations.