BIMSA >
Seminar on Bioinformatics
Combining Protein Structure Similarity Measures and Natural Vector for Potential GPCR Identification
Combining Protein Structure Similarity Measures and Natural Vector for Potential GPCR Identification
Organizer
Speaker
(Tsinghua) Tao Zhou
Time
Thursday, May 11, 2023 2:30 PM - 3:00 PM
Venue
Online
Abstract
To better identify whether a protein sequence is sufficiently close to a known GPCR sequence cluster, we have tried to use the natural vector convex hull principle. Based on this, we further introduced protein structure metrics including TM-score, RMSD and Yau-Hausdorff distance to help determine the proximity between protein sequences more precisely. I will start by introducing the calculation of these distances, then report the results of these distances on the GPCR dataset, and also describe the problems encountered in the calculation process.