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About
President
Governance
Partner Institutions
Visit
People
Management
Faculty
Postdocs
Visiting Scholars
Staff
Research
Research Groups
Courses
Seminars
Join Us
Faculty
Postdocs
Students
Events
Conferences
Workshops
Forum
Life @ BIMSA
Accommodation
Transportation
Facilities
Tour
News
News
Announcement
Downloads
Qiuzhen College, Tsinghua University
Yau Mathematical Sciences Center, Tsinghua University (YMSC)
Tsinghua Sanya International  Mathematics Forum (TSIMF)
Shanghai Institute for Mathematics and  Interdisciplinary Sciences (SIMIS)
BIMSA > Seminar on Bioinformatics Towards a unified logic underlying cell type identity
Towards a unified logic underlying cell type identity
Organizer
Shing Toung Yau
Speaker
Ruohan Ren
Time
Thursday, September 7, 2023 3:30 PM - 4:00 PM
Venue
Online
Abstract
As we all know, stem cells can generate different kinds of cells. In this process, transcriptional factors (TFs) play an important role in cell differentiation. However, what turns TFs on and keeps them expressed? Utilizing 3 flatworms as subjects, we aim to unravel the unified logic. We choose the FoxF gene as a case to illustrate the outcomes we have achieved. To unveil the regulatory patterns of FOXF genes in the 3 flatworms, we feed them into a trained deep learning model based on ChromBPNet and extract the motifs regulating the genes. Ultimately, we find that self-regulation emerges as a pivotal circuit in FOXF expression in all 3 species. Applying the similar workflow, we identify additional intriguing self-regulatory genes. Self-regulation stands as a fundamental aspect of the unified logic underlying cell type identity.
Beijing Institute of Mathematical Sciences and Applications
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