BIMSA >
Seminar on Bioinformatics
Paper review: about two approaches to the synthesis of 2D binary identifiers of DNA-associated symbol sequences
Paper review: about two approaches to the synthesis of 2D binary identifiers of DNA-associated symbol sequences
Organizer
Speaker
(Tsinghua) Tao Zhou
Time
Tuesday, December 19, 2023 3:00 PM - 3:30 PM
Venue
Online
Abstract
We will review a paper “Polarization- and Chaos-Game-Based Fingerprinting of Molecular Targets of Listeria Monocytogenes Vaccine and Fully Virulent Strains” published on current issues in molecular biology. Two approaches to the synthesis of 2D binary identifiers (“fingerprints”) of DNA-associated symbol sequences are considered in this paper, one is based on simulation of polarization-dependent diffraction patterns and another one is based on chaos game representation. The authors made a comparison of the approaches under consideration is carried out using symbol sequences corresponding to nucleotide sequences of the hly gene from the vaccine and wild-type strains of Listeria monocytogenes as the analyzed objects. They concluded that the polarization-encoded approach was more potent in terms of the detection of minor nucleotide substitutions in the target artificially generated sequences than the CGR-based binary approach, and enabled an accurate differentiation between the vaccine and wild type L.monocytogenes strains.