BIMSA > Seminar on Bioinformatics A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Organizer
Stephen S-T. Yau
Speaker
Nan Sun
Time
Thursday, February 1, 2024 10:00 PM - 10:30 PM
Venue
Online
Abstract
Single-cell genomics is essential to chart tumor ecosystems. Both scRNA-Seq and snRNA-Seq require customization to different tissue and tumor types, posing a barrier to adoption. Here, I will introduce a systematic toolbox for profiling fresh and frozen clinical tumor samples using scRNA-Seq and snRNA-Seq, respectively. The authors analyzed 216,490 cells and nuclei from 40 samples spanning eight tumor types of varying tissue and sample characteristics. This work provides guidance for studies in a broad range of tumors, including criteria for testing and selecting methods from the toolbox for other tumors, thus paving the way for charting tumor atlases.
Speaker Intro
孙楠目前是北京雁栖湖应用数学研究院的博士后。她的研究方向包括生物信息学、机器学习和应用数学，在The Innovation, Computational and Structural Biotechnology Journal, BMC Bioinformatics, Frontiers in Cellular and Infection Microbiology, Journal of Computational Biology, Genes等期刊发表多篇论文，参与多项国家自然科学基金及北京市自然科学基金项目，主持中国博士后科学基金第78批面上资助。