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About
President
Governance
Partner Institutions
Visit
People
Management
Faculty
Postdocs
Visiting Scholars
Staff
Research
Research Groups
Courses
Seminars
Join Us
Faculty
Postdocs
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Events
Conferences
Workshops
Forum
Life @ BIMSA
Accommodation
Transportation
Facilities
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News
News
Announcement
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Qiuzhen College, Tsinghua University
Yau Mathematical Sciences Center, Tsinghua University (YMSC)
Tsinghua Sanya International  Mathematics Forum (TSIMF)
Shanghai Institute for Mathematics and  Interdisciplinary Sciences (SIMIS)
BIMSA > Seminar on Bioinformatics Single Cell Convex Hull Exploration: Continued
Single Cell Convex Hull Exploration: Continued
Organizer
Shing Toung Yau
Speaker
(Tsinghua) Tao Zhou
Time
Monday, May 6, 2024 2:30 PM - 3:00 PM
Venue
理科楼A-304
Abstract
During the previous examination of the convex hull principle, we neglected quality control and preprocessing of the data, especially on gene filtering. As an example, from the perspective of gene expression, among the 10,850 genes in the dataset, the expression of MALAT1 (a LncRNA) is significantly higher than that of the remaining LncRNAs and all other genes. According to the relevant literature, the steady state expression level of MALAT1 is very high and is comparable to highly transcribed housekeeping genes. We therefore hypothesize that the presence of this housekeeping-like gene may close the distance between convex hulls. This week I will use this as a basis for presenting the impact of data quality control on the results of the convex hull principle.
Beijing Institute of Mathematical Sciences and Applications
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