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About
President
Governance
Partner Institutions
Visit
People
Management
Faculty
Postdocs
Visiting Scholars
Staff
Research
Research Groups
Courses
Seminars
Join Us
Faculty
Postdocs
Students
Events
Conferences
Workshops
Forum
Life @ BIMSA
Accommodation
Transportation
Facilities
Tour
News
News
Announcement
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Qiuzhen College, Tsinghua University
Yau Mathematical Sciences Center, Tsinghua University (YMSC)
Tsinghua Sanya International  Mathematics Forum (TSIMF)
Shanghai Institute for Mathematics and  Interdisciplinary Sciences (SIMIS)
BIMSA > Seminar on Bioinformatics Detection of protein-protein interactions from amino acid sequences using a rotation forest model with a novel pr-lpq descriptor
Detection of protein-protein interactions from amino acid sequences using a rotation forest model with a novel pr-lpq descriptor
Organizer
Shing Toung Yau
Speaker
Mengcen Guan
Time
Monday, May 13, 2024 3:00 PM - 3:30 PM
Venue
理科楼A-304
Abstract
Protein-protein interactions (PPIs) play an essential role in almost all cellular processes. In this article, a sequence-based method is proposed to detect PPIs by combining Rotation Forest (RF) model with a novel feature representation. In the procedure of the feature representation, we first adopt the Physicochemical Property Response Matrix (PR) method to transform the amino acids sequence into a matrix and then employ the Local Phase Quantization (LPQ)-based texture descriptor to extract the local phrase information in the matrix. When performed on the PPIs dataset of Saccharomyces cerevisiae, the proposed method achieves the high prediction accuracy of 93.92 % with 91.10 % sensitivity at 96.45 % precision. Compared with the existing sequence-based method, the results of the proposed method demonstrate that it is a meaningful tool for future proteomics research.
Beijing Institute of Mathematical Sciences and Applications
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