BIMSA > Seminar on Bioinformatics Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations
Integrative analysis of single-cell genomics data by coupled nonnegative matrix factorizations
Organizer
Stephen S-T. Yau
Speaker
Nan Sun
Time
Thursday, February 22, 2024 10:00 PM - 10:30 PM
Venue
Online
Abstract
When different types of functional genomics data are generated on single cells from different samples of cells from the same heterogeneous population, the clustering of cells in the different samples should be coupled. The authors formulate this “coupled clustering” problem as an optimization problem and propose the method of coupled nonnegative matrix factorizations (coupled NMF) for its solution. The method is illustrated by the integrative analysis of single-cell RNA-sequencing (RNA-seq) and single-cell ATAC-sequencing (ATAC-seq) data.
Speaker Intro
孙楠目前是北京雁栖湖应用数学研究院的博士后。她的研究方向包括生物信息学、机器学习和应用数学，在The Innovation, Computational and Structural Biotechnology Journal, BMC Bioinformatics, Frontiers in Cellular and Infection Microbiology, Journal of Computational Biology, Genes等期刊发表多篇论文，参与多项国家自然科学基金及北京市自然科学基金项目，主持中国博士后科学基金第78批面上资助。