BIMSA >
Moscow-Beijing topology seminar
Applications of GLMY theory in metabolomic networks of complex diseases
Applications of GLMY theory in metabolomic networks of complex diseases
Organizers
Vassily Manturov
, Shiquan Ren
,
Zhe Yan Wan
Speaker
Time
Wednesday, August 14, 2024 3:30 PM - 5:00 PM
Venue
A3-2-301
Online
Zoom 831 5020 0580
(141592)
Abstract
Human diseases involve metabolic alterations. Metabolomic profiles have served as a biomarker for the early identification of high-risk individuals and disease prevention. However, current approaches can only characterize individual key metabolites, without taking into account their interactions.This work have leveraged a statistical physics model to combine all metabolites into bDSW networks and implement GLMY homology theory to analyze and interpret the topological change of health state from symbiosis to dysbiosis.The application of this model to real data allows us to identify several hub metabolites and their interaction webs, which play a part in the formation of inflammatory bowel diseases.