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Applications of GLMY theory in metabolomic networks of complex diseases

组织者

Vassily Manturov , 任世全 , 万喆彦

演讲者

吴双

时间

2024年08月14日 15:30 至 17:00

地点

A3-2-301

线上

Zoom 831 5020 0580 (141592)

摘要

Human diseases involve metabolic alterations. Metabolomic profiles have served as a biomarker for the early identification of high-risk individuals and disease prevention. However, current approaches can only characterize individual key metabolites, without taking into account their interactions.This work have leveraged a statistical physics model to combine all metabolites into bDSW networks and implement GLMY homology theory to analyze and interpret the topological change of health state from symbiosis to dysbiosis.The application of this model to real data allows us to identify several hub metabolites and their interaction webs, which play a part in the formation of inflammatory bowel diseases.