Evolutionary Game Theory Acts in the Dysbiotic Gut Microbiota
Organizers
Speaker
Tianchen Gao
Time
Wednesday, October 25, 2023 2:00 PM - 3:45 PM
Venue
Shuangqing-B725
Abstract
This report primarily discusses how evolutionary game theory can be used to interpret the dysbiotic gut microbiota of inflammatory bowel disease (IBD) patients. We will focus on one of two types of IBD - ulcerative colitis (UC). The pathogenesis of UC is believed to be closely related to the shift of the gut microbiota from symbiosis to dysbiosis, and this shift leads to the abnormal activation of the immune system and the occurrence of inflammation. Here, we integrate the principle of evolutionary game theory to formulate the mathematical equations describing how microbes interact with each other in the gut microbiota. These equations found a basis for the reconstruction of informative, dynamic, omnidirectional, and personalized networks (idopNetwork). The topological analysis of idopNetwork can help to identify key microbial interaction pathways underlying the shift of the gut microbiota from the symbiosis to dysbiosis and vice versa. I will demonstrate this idea by analyzing a real dataset of the gut microbiota.
Speaker Intro
高天辰，厦门大学在读博士生，师从刘婧媛教授，主要研究方向为复杂网络数据的统计建模。在《Journal of the Royal Statistical Society. Series C: Applied Statistics》、《Statistics and Its Interface》等期刊发表SCI论文3篇.