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BIMSA Lecture
A Unified Whole-Body Closed-Loop Multiscale Framework for Hemodynamic Regulation and Flow Redistribution under Pathological Conditions
A Unified Whole-Body Closed-Loop Multiscale Framework for Hemodynamic Regulation and Flow Redistribution under Pathological Conditions
组织者
演讲者
刘嘉玮
时间
2025年10月27日 15:00 至 16:30
地点
Shuangqing B626
线上
Zoom 712 322 9571
(BIMSA)
摘要
This presentation introduces a unified mathematical and computational framework for multiscale hemodynamic modeling, coupling systemic, cerebral, and cardiac dynamics under physiological and pathological conditions. The model integrates one-dimensional flow model for arterial, venous, and portal venous systems, zero-dimensional lump-parameter models for vascular subsystems corresponding to peripheral arteries and organs. Efficient parallel algorithms for the multicore environments have been presented, achieving approximately 20-fold acceleration on a 24-core CPU platform.
For the brain, a cerebral autoregulation mechanism (CAM) is integrated with a three-dimensional-reconstructed Circle of Willis (CoW) network, enabling the quantification of collateral activations under anatomical variations and stenosis. The model reproduces experimental Doppler results and provides a physiologically interpretable explanation of cerebral blood flow redistribution.
For the heart, a time-dependent HR(t)–PV loop coupling framework captures how heart rate curvature influences ventricular pressure–volume dynamics. Combined with wearable HR data, this approach bridges model-based physiology and real-world measurements, supporting individualized cardiac performance evaluation.
An interactive simulation app covering the whole-body, heart–pulmonary, cerebral, and Circle of Willis modules has been developed, in collaboration with medical teams to facilitate clinical interpretation and translational applications.
演讲者介绍
Dr. Jiawei Liu is currently an Assistant Professor at the Advanced Institute for Materials Research (AIMR), Tohoku University, Japan. She received her Ph.D. in Applied Mathematics from Tsinghua University and previously worked as a postdoctoral researcher at the School of Geosciences and Info-physics, Central South University. Her research focuses on seismic wave propagation, stability analysis and numerical simulation of partial differential equations, and the development of scientific computing tools based on MATLAB App Designer. She has authored more than ten papers as the first or corresponding author in journals such as Geophysical Journal International and Geophysical Prospecting, and holds three granted Chinese invention patents. Dr. Liu has led a provincial Natural Science Foundation project and contributed to two General Programs supported by the National Natural Science Foundation of China.