北京雁栖湖应用数学研究院

胡丕丕

刘嘉玮

2025年10月27日 15:00 至 16:30

Shuangqing B626

Zoom 712 322 9571 (BIMSA)

This presentation introduces a unified mathematical and computational framework for multiscale hemodynamic modeling, coupling systemic, cerebral, and cardiac dynamics under physiological and pathological conditions. The model integrates one-dimensional flow model for arterial, venous, and portal venous systems, zero-dimensional lump-parameter models for vascular subsystems corresponding to peripheral arteries and organs. Efficient parallel algorithms for the multicore environments have been presented, achieving approximately 20-fold acceleration on a 24-core CPU platform. For the brain, a cerebral autoregulation mechanism (CAM) is integrated with a three-dimensional-reconstructed Circle of Willis (CoW) network, enabling the quantification of collateral activations under anatomical variations and stenosis. The model reproduces experimental Doppler results and provides a physiologically interpretable explanation of cerebral blood flow redistribution. For the heart, a time-dependent HR(t)–PV loop coupling framework captures how heart rate curvature influences ventricular pressure–volume dynamics. Combined with wearable HR data, this approach bridges model-based physiology and real-world measurements, supporting individualized cardiac performance evaluation. An interactive simulation app covering the whole-body, heart–pulmonary, cerebral, and Circle of Willis modules has been developed, in collaboration with medical teams to facilitate clinical interpretation and translational applications.

Dr. Jiawei Liu is currently an Assistant Professor at the Advanced Institute for Materials Research (WPI-AIMR), Tohoku University, Japan. She received her Ph.D. degree from Tsinghua University and previously worked as a Postdoctoral Research Fellow at the School of Geophysics and Information Physics, Central South University, China. Her research interests include multiscale modeling of the human circulatory system, coupled regulation of cerebral and cardiovascular hemodynamics, and parallel numerical simulation of physiological systems. She has developed an interactive visualization and simulation app integrating whole-body circulation, cerebral blood flow, and heart–lung dynamics, which is now being jointly studied with medical teams from The University of Tokyo and Tohoku University. Dr. Liu has published more than ten papers as the first or corresponding author in international journals such as Geophysical Journal International and Geophysical Prospecting, led one provincial-level Natural Science Foundation project, and holds three national invention patents. Her current research focuses on establishing a unified theoretical and computational framework for understanding and predicting blood circulatory regulation of the whole body and disease progression through multiscale modeling and computational physiology.