- 生物信息讨论班

Evolutionary dynamics of polygenic traits in finite populations under natural selection

组织者

丘成栋

演讲者

吴琦

时间

2024年01月20日 21:30 至 22:00

地点

Online

摘要

When heritable traits are determined by multiple genes, they are called polygenic traits. For a population composed of a group of individuals, the polygenic trait of interest has an observable phenotype value label on each individual in the population. A simple example is that each person in a population can measure their height value. Evolution occurs at the population level, shaping the genetic diversity of the traits of interest in this group of individuals through the combined effects of natural selection, mutation, neutral drift, and other driving forces. The classic evolutionary quantitative genetics explores the evolution of polygenic traits in situations where the genetic diversity of traits is not significantly different. Actually, there are many theoretical difficulties in predicting the evolution of such traits over longer time scales or in situations where the phenotypic changes of traits are significant. In this seminar, we aim to explore whether a theoretically plausible and mathematically operable model can be obtained under certain constraints, in order to predict the long-term or large-scale evolution of more polygenic traits.