The advanced evolutionary theory of polygenic trait
This course is a course on the theory of natural selection and long-term evolution of polygenic traits. The course content is based on the mathematical theory of the evolution of complex(quantitative) traits, and the final concern is the synthesis of palaeobiology theory and genetics theory in the evolutionary theory (I believe this is a certain direction and trend in the future of evolutionary biology). From the perspective of evolutionary theory and thought, the course will introduce some basic contents of the long-term evolution theory of polygenic traits at the population level. This COURSE IS NOT AN INTRODUCTION TO A COMPLETED theoretical framework, but rather TO a set OF open theoretical PROBLEMS AND explorations to date. It provides a window for students who are interested in the theory of life evolution to understand the general situation of the field. This course is led by the The "evolutionary theory of polygenic trait - I".
本课程是一门讲授多基因性状的自然选择与长期演化理论的课程的高阶部分。课程总体以复杂性状（数量性状）长期演化的数学理论为线索，以进化论中古生物学理论和遗传学理论的大综合为最终关切（这是未来进化生物学的某种方向和趋势）。在本部分中，从进化理论和思想视角出发串讲多基因性状在种群水平长期演化理论的若干基本内容。此课程不是在介绍一个已经完成的理论框架，而是意在介绍一系列开放的理论问题以及到目前为止的探索。为有志于生命演化理论研究的学子提供一个了解领域概貌的窗口。本课程以 "The evolutionary theory of polygenic trait - I" 为先导课程。
本课程是一门讲授多基因性状的自然选择与长期演化理论的课程的高阶部分。课程总体以复杂性状（数量性状）长期演化的数学理论为线索，以进化论中古生物学理论和遗传学理论的大综合为最终关切（这是未来进化生物学的某种方向和趋势）。在本部分中，从进化理论和思想视角出发串讲多基因性状在种群水平长期演化理论的若干基本内容。此课程不是在介绍一个已经完成的理论框架，而是意在介绍一系列开放的理论问题以及到目前为止的探索。为有志于生命演化理论研究的学子提供一个了解领域概貌的窗口。本课程以 "The evolutionary theory of polygenic trait - I" 为先导课程。
讲师
日期
2026年09月16日 至 2027年01月06日
位置
| Weekday | Time | Venue | Online | ID | Password |
|---|---|---|---|---|---|
| 周三 | 14:20 - 16:55 | Shuimo | Tencent A | 482 969 7386 | 106457 |
修课要求
the evolutionary theory of polygenic trait - I
课程大纲
I the neutral theory of molecular evolution
II theorems of natural selection: results of Price, Fisher and Robertson (1)
III theorems of natural selection: results of Price, Fisher and Robertson (2)
IV changes in gentic variance induced by drift (1)
V changes in gentic variance induced by drift (2)
VI the neutral divergence of quantitative traits
VII short-term changes in the mean and variance
VIII the infinitesimal model for quiantitative traits (1)
IX the infinitesimal model for quiantitative traits (2)
X Long-term response: 1. deterministic aspects
XI Long-term response: 2. finite population size and mutation (1)
XII Long-term response: 2. finite population size and mutation (2)
XIII Long-term response: 3. adaptive walks and Fisher's Geometry model (1)
XIV Long-term response: 3. adaptive walks and Fisher's Geometry model (2)
XV Maintenance of quantitative genetic variation (1)
XVI Maintenance of quantitative genetic variation (2)
II theorems of natural selection: results of Price, Fisher and Robertson (1)
III theorems of natural selection: results of Price, Fisher and Robertson (2)
IV changes in gentic variance induced by drift (1)
V changes in gentic variance induced by drift (2)
VI the neutral divergence of quantitative traits
VII short-term changes in the mean and variance
VIII the infinitesimal model for quiantitative traits (1)
IX the infinitesimal model for quiantitative traits (2)
X Long-term response: 1. deterministic aspects
XI Long-term response: 2. finite population size and mutation (1)
XII Long-term response: 2. finite population size and mutation (2)
XIII Long-term response: 3. adaptive walks and Fisher's Geometry model (1)
XIV Long-term response: 3. adaptive walks and Fisher's Geometry model (2)
XV Maintenance of quantitative genetic variation (1)
XVI Maintenance of quantitative genetic variation (2)
参考资料
Bruce Walsh & Michael Lynch. Evolution and Selection of Quantitative Traits. Oxford University Press. 2018.
Michael Lynch & Bruce Walsh. Genetics and Analysis of QUantitative Traits. Oxford University Press. 1998.
Daniel Hartl，Andrew Clark. Principles of Population Genetics, Fourth Edition, Sinauer Associates, Inc. 2007.
Warren J. Ewens. Mathematical Population Genetics. Springer. 2004-1.
刘祖洞、吴燕华、乔守怡、赵寿元。遗传学（第4版），高等教育出版社，2021-3.
Michael Lynch & Bruce Walsh. Genetics and Analysis of QUantitative Traits. Oxford University Press. 1998.
Daniel Hartl，Andrew Clark. Principles of Population Genetics, Fourth Edition, Sinauer Associates, Inc. 2007.
Warren J. Ewens. Mathematical Population Genetics. Springer. 2004-1.
刘祖洞、吴燕华、乔守怡、赵寿元。遗传学（第4版），高等教育出版社，2021-3.
听众
Advanced Undergraduate
, Graduate
视频公开
公开
笔记公开
公开
语言
中文
, 英文
讲师介绍
吴琦，2024年6月受聘于北京雁栖湖应用数学研究院，开展复杂性状演化建模。以（并列）一作或通讯作者在Science，Nature Genetics，PNAS，SCLS等期刊发表论文30余篇。